At the beginning of the play, we see that Lady Macbeth is Macbeth's biggest support. When he falters in his belief to go after his ambitions, she encourages him by being dominant and eloquent. She questions his strength and manhood when she hears that he hesitates to murder Duncan. Macbeth can rely on his wife, and she is his accomplice when he murders Duncan and takes the throne. In short, Macbeth and Lady Macbeth love, understand, and support each other.
However, when Macbeth becomes the leader, he changes drastically. His wife assumes a less important role in his life and becomes neglected because Macbeth is preoccupied with retaining his power and ensuring that he is harmed by no one.
In Act 5, Lady Macbeth becomes tormented by her guilt-ridden conscience and her husband's lack of care, so her descent into madness is clear. Her death causes Macbeth to come to conclusion that life is futile.
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